Indications: Aid in the treatment of noninfectious joint diseases in dogs, including osteoarthritis, especially in conditions affecting multiple joints; osteochondrosis dissecans; traumatic joint and periarticular inflammation in working and racing dogs.
Actions: Synovan Injection for Dogs contains Pentosan Polysulfate sodium (PPS) which stimulates joint healing and repair, and reduces inflammation to help reverse the effects of osteoarthritis, as well as NAG (Acetyl Glucosamine) a newly approved and more advanced form of glucosamine that has been shown to improve glycosaminoglycan and hyaluronic acid synthesis compared to glucosamine (Shikhman AR et al 2009). Synovan possesses anti-inflammatory, anti-arthritic and chondroprotective properties. These beneficial effects arise from direct anti-inflammatory activity, inhibition of neutrophil migration into joints, stimulation of hyaluronic acid synthesis by synovial fibroblasts which results in a marked increase in synovial fluid volume and viscosity; stimulation of chondrocytes, and the biosynthesis of proteoglycans; and a strong fibrinolytic activity which improves the circulation in subchondral bone and periarticular structures.
Treatment using the combination of anti-arthritic agents Pentosan Polysulfate sodium and NAG (Acetyl Glucosamine) in Synovan may result in a greater anti-inflammatory effect than either active alone (Heinecke LF et al 2010, Data on File), which helps reduce joint swelling and improve mobility (Data on File).
Dosage Regimen: Injection on four occasions with an interval of 5 - 7 days between injections. After the initial course of 4 injections, single injections may be repeated as required at the discretion of a veterinarian.
For administration by a veterinarian.
Not for sale over the counter.